| Triclosan의 독성에 중금속이 미치는 영향 - V. fischeri Assay 관련 내용 중심으로 - |
| 김지성1, 김일호1,2, 이우미3, 이혜인2, 김석구1,2 |
1과학기술연합대학원대학교 건설환경공학과
2한국건설기술연구원 수자원 환경 연구본부 환경연구실
3금강유역환경청 |
| A Effect of Heavy Metal to Toxicity of Triclosan Focused on Vibrio fischeri Assay |
| Ji-Sung Kim1, IL-Ho Kim1,2, Woo-Mi Lee3, Hye-in Lee2, Seok-Gu Kim1,2 |
1Department of Construction Environment Engineering, University of Science and Technology
2Environmental Engineering Research Division, Korea Institute of Construction Technology
3Geum River Basin Environmental Office |
| Corresponding author |
IL-Ho Kim ,Tel: 031-910-0649, Fax: 031-910-0291, Email: ihkim@kict.re.kr
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Received: November 15, 2013; Accepted: February 17, 2014. Published online: March 31, 2014. |
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| ABSTRACT |
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The purpose of this study is to evaluate effect of heavy metals (i.e., Cu2+, Zn2+, Cr6+, Cd2+, Hg2+, and Pb2+) to toxicity of Triclosan as binary mixture. The individual toxicity and combined toxic effects of Triclosan with heavy metals were evaluated by Vibrio fischeri assay. In individual toxicity, the Hg2+ was found to be most toxic followed by Triclosan, Pb2+, Cr6+, Cu2+, Zn2+, and Cd2+, respectively. To evaluate combined toxic effect, correlation analysis of ‘predicted value’ calculated by Concentration addition (CA) model and Independent action (IA) model with ‘experimental value’ were performed based on the toxicity of individual compound. As a result, all of the combinations showed that IA model were more correlated with experimental value than CA model. On the basis of the median effect concentration of combination (EC50mix) predicted by IA model, experimental EC50mix of Triclosan + Cu, Triclosan + Zn, Triclosan + Pb, Triclosan + Hg, Triclosan + Cd, and Triclosan + Cr were 191%, 226%, 138%, 137%, 209%, and 138% of EC50mix predicted by IA model, respectively, indicating that all of the combinations produced antagonistic effect. |
| Key Words:
Combined Toxicity, Heavy Metal, Triclosan, Vibrio fischeri |
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